Six of Spurs' starters could be impacted.
Tottenham have been hit by a Covid-19 outbreak ahead of Thursday's Europa Conference League match against Rennes.
Up to six Tottenham first-team players and two members of backroom staff are believed to have tested positive for Covid, and Spurs are waiting for the results of PCR tests to confirm the extent of the problem.
The 10-day period of self-isolation for anyone who tests positive means Spurs' players hit by the outbreak are set to miss their next three games. This comes ahead of the busy pre-Christmas portion of the season.
After facing Rennes, Antonio Conte's side return to Premier League action with a trip to Brighton on Sunday, before they travel to Leicester City next Thursday and host Liverpool on December 19.
This past weekend in America, the MLS's Philadelphia Union were forced to field a vastly understrength side in the Eastern Conference final against New York City FS because 11 players were placed in the league's Health and Safety protocols.
Let's hope all recover quickly.